Not finding the right medicine? We can help
Fotivda (tivozanib)
We can help with your prescription. Read the “Prescription Guide”.
You can access this medicine even if it's not approved in your country. Learn how.
Disease Indications
Kidney Cancer
Manufacturer
EUSA Pharma
Usage
Oral
Medicine approved by
-
European Medical Agency (EMA)
-
Food and Drug Administration (FDA)
Patients helped
- Over 1.2 million patients reached
- More than 11,000 patients helped
- 100% successful deliveries to 88 countries
We can help with your import documents
We are experts in import regulations. Scroll below to download the import guide for your country.
FREQUENTLY ASKED QUESTIONS
We help you access approved medicines that are not approved or available in your country of residence.
Legal
We help you access approved medicines that are not approved or available in your country of residence.
Legal
Finances
Payment
- Your permanent residence is outside the European Union
- You take the medicines with you, unused within 90 days after purchase
- You have a full original receipt (which we provide you)
Unfortunately, we are unable to help with VAT refunds following delivery or collection from our partner pharmacies outside of the Netherlands.
- If you are residing within the European Union and you are not a company
- If you are coming to Amsterdam, Luxembourg or Dusseldorf to pick up your order
In case of pick up, you may be eligible for a VAT tax refund if you live outside the European Union.
Price
Reimbursement
- That you want to import an approved medicine from abroad
- The lack of reasonable treatment options available in your country (if you can, include a letter from a doctor confirming this) - no alternative to the treatment.
- That the medicine has already been approved in another country (state the name of the country)
- That your treating doctor states that this medicine is the best option for you (include a copy of the prescription in the letter to the healthcare insurance company)
Ordering and shipping
Ordering
- Name of the patient
- Contact details of patient(email and phone number)
- Copy of patient’s ID
- Contact details of the Doctor (name, address, email and phone number)
- Shipping address
- Copy of the doctor's prescription
Shipping: We can deliver to the patient's residence, a pharmacy, or doctor's office / hospital, but this depends on the country. If you’re not sure what the right choice is for you, please get in touch with our Patient Support Team and we can help you work out your exact requirements.
Once we have received this information, one of our Patient Support Team members will then check your prescription and contact you to follow up on your order. Please note that other documents may be needed for import, we will guide you through the ordering process.
Generally not, but we do provide you with an invoice after you make the payment that you may send to your medical insurance company so they can reimburse you. In some limited circumstances, we do accept insurance. Contact us for more details.
As part of our protocols we might reach out to your treating doctor for verification or information updates. By sending us your prescription you allow us to do so.
- Patient's name and date of birth
- Name of the medicine and dosage
- Required quantity
- Doctor's name and signature
- Doctor's registration number and/or stamp
Ideally, the prescription should be issued in English. Alternatively, a translation (unofficial is sufficient) must be provided.
Please be aware that your doctor may be contacted by one of our team members or by the processing pharmacy in order to verify the prescription.
Shipping
Please be aware that due to the COVID-19 situation worldwide and the country lockdowns, we will sometimes experience delays in shipping.
For EMA approved medicines with prescriptions from within the Schengen zone, you can pick the medicines up from our partner pharmacy in Amsterdam, Luxembourg or Dusseldorf. For non-EMA approved medicines, with prescriptions from within the Schengen zone, you can pick the medicines up in our partner pharmacy in Dusseldorf. If you have requested to collect your medicines, you will receive a notification when the medicines are in the pharmacy and ready for you.
There are also options to deliver the medicines to other countries. Please get in touch with our Patient Support Team to discuss which other pick-up and delivery options may be suitable for you.
- Copy of the ID/passport of the patient
- Copy of the ID/passport of the person who is coming to pick up the medicines
- Letter signed by the patient stating that he/she authorises this person to pick up the medicines on his/her behalf
- Step 1 - Customs may need to check the package to verify its contents. In order to streamline this step, we include a letter for customs with information about the contents. Any additional questions will be answered by everyone.org as and when we are contacted by customs.
- Step 2 - In some countries, there are additional questions from the medical regulatory agencies (i.e. the FDA, EMA, etc). We provide them with all the necessary information based on the information provided by the patient, such as: the prescription, copy of ID and a letter from the treating doctor to show that the medicines are for personal use.
- Step 3 - Customs fees. In some cases, the recipient will be requested to pay taxes and duties. These should be arranged by the patient or receiver and are not covered by everyone.org unless stated otherwise.
Please be aware that the import of the medicines always requires customs clearance and active cooperation from the importing party. We will help and guide you but are dependent on your cooperation and responsiveness.
About us
- Complete the enquiry form on our Contact Us page
- Send an email: [email protected]
- Call us on:
- +31 20 808 4414 (EU)
- +1 646 381 0675 (US)
- +61 28 417 2910 (AUS)
Others
Available medicines
Medicine approval
The respective national and regional agencies, such as the Food and Drugs Administration (FDA) in the USA or the European Medical Authority (EMA) for the European Union assess these applications and make a decision on whether to approve new medicines. The review process is based on evaluation of the evidence provided by the company. Every agency uses a slightly different process.
- Phase I - performed in a small number of healthy volunteers or very sick patients with lack of treatment options, designed to study the effects of the medicine in the human body.
- Phase II - larger number of patients, designed to evaluate the safety and efficacy of the medicine and to determine if different dosages of the treatment have different effects.
- Phase III - large number of patient groups, designed to confirm the safety and efficacy of the medicine.
- Phase IV - after the medicine has received regulatory approval, designed to evaluate the long-term effects.
Updates
Finances
Payment
- Your permanent residence is outside the European Union
- You take the medicines with you, unused within 90 days after purchase
- You have a full original receipt (which we provide you)
Unfortunately, we are unable to help with VAT refunds following delivery or collection from our partner pharmacies outside of the Netherlands.
- If you are residing within the European Union and you are not a company
- If you are coming to Amsterdam, Luxembourg or Dusseldorf to pick up your order
In case of pick up, you may be eligible for a VAT tax refund if you live outside the European Union.
Price
Reimbursement
- That you want to import an approved medicine from abroad
- The lack of reasonable treatment options available in your country (if you can, include a letter from a doctor confirming this) - no alternative to the treatment.
- That the medicine has already been approved in another country (state the name of the country)
- That your treating doctor states that this medicine is the best option for you (include a copy of the prescription in the letter to the healthcare insurance company)
Ordering and shipping
Ordering
- Name of the patient
- Contact details of patient(email and phone number)
- Copy of patient’s ID
- Contact details of the Doctor (name, address, email and phone number)
- Shipping address
- Copy of the doctor's prescription
Shipping: We can deliver to the patient's residence, a pharmacy, or doctor's office / hospital, but this depends on the country. If you’re not sure what the right choice is for you, please get in touch with our Patient Support Team and we can help you work out your exact requirements.
Once we have received this information, one of our Patient Support Team members will then check your prescription and contact you to follow up on your order. Please note that other documents may be needed for import, we will guide you through the ordering process.
Generally not, but we do provide you with an invoice after you make the payment that you may send to your medical insurance company so they can reimburse you. In some limited circumstances, we do accept insurance. Contact us for more details.
As part of our protocols we might reach out to your treating doctor for verification or information updates. By sending us your prescription you allow us to do so.
- Patient's name and date of birth
- Name of the medicine and dosage
- Required quantity
- Doctor's name and signature
- Doctor's registration number and/or stamp
Ideally, the prescription should be issued in English. Alternatively, a translation (unofficial is sufficient) must be provided.
Please be aware that your doctor may be contacted by one of our team members or by the processing pharmacy in order to verify the prescription.
Shipping
Please be aware that due to the COVID-19 situation worldwide and the country lockdowns, we will sometimes experience delays in shipping.
For EMA approved medicines with prescriptions from within the Schengen zone, you can pick the medicines up from our partner pharmacy in Amsterdam, Luxembourg or Dusseldorf. For non-EMA approved medicines, with prescriptions from within the Schengen zone, you can pick the medicines up in our partner pharmacy in Dusseldorf. If you have requested to collect your medicines, you will receive a notification when the medicines are in the pharmacy and ready for you.
There are also options to deliver the medicines to other countries. Please get in touch with our Patient Support Team to discuss which other pick-up and delivery options may be suitable for you.
- Copy of the ID/passport of the patient
- Copy of the ID/passport of the person who is coming to pick up the medicines
- Letter signed by the patient stating that he/she authorises this person to pick up the medicines on his/her behalf
- Step 1 - Customs may need to check the package to verify its contents. In order to streamline this step, we include a letter for customs with information about the contents. Any additional questions will be answered by everyone.org as and when we are contacted by customs.
- Step 2 - In some countries, there are additional questions from the medical regulatory agencies (i.e. the FDA, EMA, etc). We provide them with all the necessary information based on the information provided by the patient, such as: the prescription, copy of ID and a letter from the treating doctor to show that the medicines are for personal use.
- Step 3 - Customs fees. In some cases, the recipient will be requested to pay taxes and duties. These should be arranged by the patient or receiver and are not covered by everyone.org unless stated otherwise.
Please be aware that the import of the medicines always requires customs clearance and active cooperation from the importing party. We will help and guide you but are dependent on your cooperation and responsiveness.
About us
- Complete the enquiry form on our Contact Us page
- Send an email: [email protected]
- Call us on:
- +31 20 808 4414 (EU)
- +1 646 381 0675 (US)
- +61 28 417 2910 (AUS)
Others
Available medicines
Medicine approval
The respective national and regional agencies, such as the Food and Drugs Administration (FDA) in the USA or the European Medical Authority (EMA) for the European Union assess these applications and make a decision on whether to approve new medicines. The review process is based on evaluation of the evidence provided by the company. Every agency uses a slightly different process.
- Phase I - performed in a small number of healthy volunteers or very sick patients with lack of treatment options, designed to study the effects of the medicine in the human body.
- Phase II - larger number of patients, designed to evaluate the safety and efficacy of the medicine and to determine if different dosages of the treatment have different effects.
- Phase III - large number of patient groups, designed to confirm the safety and efficacy of the medicine.
- Phase IV - after the medicine has received regulatory approval, designed to evaluate the long-term effects.
Updates
Fotivda (tivozanib)
Package
Capsules
Where can we deliver?
We have delivered medicines to more than 88 countries. Check if we have sent medicines to yours.
We currently can’t ship medicines to - contact us for alternative options.
Make an enquiry to receive information about the different options of obtaining for a patient in .
We haven’t shipped medicines to yet. You can count on us to make it happen.
Make an enquiry to receive information about the cost, shipping time and import details for .
Yes, we have successfully delivered medicines to .
Make an enquiry to receive information about the cost, shipping time and import details for .
PICK-UP IN PERSON FROM A PARTNER PHARMACY
We can arrange for you to pick up this medicine from our partner pharmacy in Luxembourg. Read more.
Pick-up from Luxembourg.
Depending on your particular circumstance, this option can be cheaper and require less paperwork than direct delivery. You can ask someone else to pick up the medicine on your behalf.
In some cases, medicines can be picked up from partner pharmacies in Amsterdam (the Netherlands) or Dusseldorf (Germany).
Tell our Patient Support Team if you’re interested in pick-up options for your order.
GDP compliant. View certificate.
Licensed wholesale distributor. View certificate.
What is Fotivda (tivozanib) for?
Fotivda is a kinase inhibitor indicated for the treatment of adults with advanced kidney cancer (advanced renal cell carcinoma or RCC) that has been treated with 2 or more prior medicines and has come back (relapsed) or did not respond to treatment (refractory).1
It is available in capsule form, containing either 1.34 mg or 0.89 mg tivozanib.1
How does Fotivda (tivozanib) work?
Renal cell cancer (RCC) - also called kidney cancer or renal cell adenocarcinoma - is a disease in which cancer cells are found in the lining of tubules in the kidney.2
Tivozanib is a vascular endothelial growth factor receptor (VEGFR) kinase inhibitor. The VEGFR is a protein that plays an important role in the formation of new blood vessels, in a process called angiogenesis. This process is critical in cancer development. It makes it possible that cancer cells proliferate, migrate and survive. There are three types of VEGFRs, and blocking all three of them will have the optimal effect in stopping cancer angiogenesis.3
Tivozanib can block all three VEGFRs and thereby stop the formation of new blood vessels that the tumor needs, thereby cutting off its blood supply and reducing the growth of the cancer.1,3
Where has Fotivda (tivozanib) been approved?
Fotivda (tivozanib) was approved for the treatment of people with HoFH by:
- The European Medicines Agency (EMA) on August 28, 2017.4
- The Food and Drug Administration (FDA), USA on March 10, 2021.5
Initially, the FDA rejected the new drug application, based on inconsistent progression-free and overall survival results, as well as imbalance in post-study treatments.6
Please note that this medicine may have also been approved in other regions than the ones we’ve listed. If you have a question about its approval in a specific country feel free to contact our support team.
How is Fotivda (tivozanib) taken?
The standard dosage is:1
- 1.34 mg taken orally once daily for 21 days, followed by a 7 day rest period for a 28-day cycle.
This 28-day cycle should be repeated for as long as the disease does not get worse or until side effects become unacceptable. If you experience troublesome side effects, the treating doctor may decide to switch to the lower-strength 0.89 mg capsules or interrupt treatment.1
No more than one dose of Fotivda (tivozanib) must be taken per day.1
Take capsules with or without food. Swallow the capsule whole with a glass of water. Do not open the capsule.1
Warning: Do not take St John’s wort (a herbal remedy for depression) during treatment with Fotivda (tivozanib).1
Complete information about Fotivda (tivozanib) dosage and administration and the full list of restrictions can be found in the official prescribing information listed in our references section.1
Note: Please consult with your treating doctor for personalised dosing.
Are there any known adverse reactions or side effects of Fotivda (tivozanib)?
Common adverse reactions
The most common side effects ( ≥10% of patients) listed in the prescribing information include:1
- Difficulty speaking
- Diarrhoea
- Loss of appetite; weight loss
- Headache
- Difficult breathing; shortness of breath during exercise; coughing
- Tiredness; unusual weakness; pain (including in the mouth, bone, extremities, side of the body, groin, tumor)
- Inflammation of the mouth; slight mouth pain or discomfort; feeling sick; pain, discomfort and tightness in the stomach
- Hand-foot-syndrome with skin reddening, swelling, numbness and skin peeling on palms and soles
- Back pain
- Tiredness and lack of energy
Serious adverse reactions
The serious adverse reactions listed in the prescribing information include:1
- High blood pressure (hypertension)
Use in a specific population
Fotivda (tivozanib) can cause harm to a fetus. Pregnancy and breastfeeding should be avoided. Effective methods of contraception should be used by male and female patients and their partners during therapy, and for at least one month after completing therapy. It is not yet known whether Fotivda (tivozanib) may reduce the effectiveness of hormonal contraceptives and therefore women using hormonal contraceptives should add a barrier method.1
For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information.1
References
1. Full prescribing information [EMA]: Fotivda (tivozanib) [PDF]
Aveo Oncology, Aug 2017
2. Renal Cell Cancer Treatment
Cancer.gov, cited Mar 2021
3. Tivozanib
Aveo Oncology, cited Mar 2021
4. EUSA Pharma and AVEO Oncology Announce the First Commercial Launch of FOTIVDA® (tivozanib)
Aveo Oncology press release, Aug 2017
5. AVEO Oncology Announces U.S. FDA Approval of FOTIVDA® (tivozanib) for the Treatment of Adult Patients with Relapsed or Refractory Advanced Renal Cell Carcinoma
Aveo Oncology press release, Mar 2021
6. FDA Rejects Renal Cancer Drug Tivozanib
Medpagetoday.com, cited Mar 2021
The European Medicines Agency (EMA) approval of Fotivda (tivozanib) for treatment of adults with advanced renal cell carcinoma (RCC) was based on data of the TIVO-1 study (NCT01030783).1
The Food and Drug Administration (FDA) approval of Fotivda (tivozanib) for adults with advanced RCC was based on data of an additional study: TIVO-3.2
TIVO-1 was an open-label, randomized, controlled, multi-national, multi-center, parallel-arm trial comparing tivozanib to sorafenib (standard of care for RCC) in advanced RCC. the study involved 517 patients with advanced RCC. Patients receiving tivozanib received 1.5 mg orally once daily, beginning on day 1 for 21 days followed by 1 week off treatment, in cycles of 28 days. Cycles were repeated every 4 weeks. Patients receiving sorafenib received 400 mg orally twice daily continuously, beginning on day 1.3
Like TIVO-1, TIVO-3 was a phase 3, open-label, randomized, controlled, multi-national, multi-center, parallel-arm trial. The trial involved 350 patients with advanced RCC who received either tivozanib or sorafenib.4
Results
The main efficacy outcome of both studies was progression-free survival (PFS), which is defined as the time from start of the trial to the first moment tumor progression is seen or the patient dies due to any reasons whichever comes first.3,4
Results of the studies show that tivozanib can help stop the disease from getting worse. Patients taking tivozanib lived for longer without their disease worsening than those given another approved medicine sorafenib.5,6
- In TIVO-1, PFS was 11.9 months in patients taking tivozanib compared with 9.1 months associated with sorafenib.3
- In TIVO-3, PFS was 5.6 months in patients taking tivozanib versus compared with 3.9 months associated with sorafenib.
In TIVO-1, PFS specifically in the 70% of trial patients who were treatment naive (who previously did not receive another therapy) was 12.7 months for those treated with tivozanib and 9.1 months for those receiving sorafenib.5
Please refer to the summary of product characteristics below and in the resource section for comprehensive information about the safety and effectiveness of Fotivda (tivozanib) for the approved indication.7
References
1. EUSA Pharma and AVEO Oncology Announce the First Commercial Launch of FOTIVDA® (tivozanib)
Aveo Oncology press release, Aug 2017
3. A Study to Compare Tivozanib (AV-951) to Sorafenib in Subjects With Advanced Renal Cell Carcinoma (TIVO-1)
Clinical Trial, cited Mar 2021
4. A Study to Compare Tivozanib Hydrochloride to Sorafenib in Subjects With Refractory Advanced RCC
Clinical Trial TIVO-3, cited Mar 2021
5. Phase III Results Lead Aveo and Astellas to Plan Regulatory Submissions for Tivozanib
Genetic Engineering & Biotechnology News, Jan 2012
6. Tivozanib versus sorafenib in patients with advanced renal cell carcinoma (TIVO-3): a phase 3, multicentre, randomised, controlled, open-label study
Rini, BI, et al., Lancet Oncol, Jan 2020
7. Full prescribing information [EMA]: Fotivda (tivozanib) [PDF]
Aveo Oncology, Aug 2017
Fotivda (tivozanib) price in other currencies*
| Package | Euro | Australian dollars | Canadian dollar | New Zealand dollar | Nigerian naira | Singapore dollar | Pound sterling | United States dollar |
|---|---|---|---|---|---|---|---|---|
| 21 capsules of 1340 mcg | 4763 EUR | 7868 AUD | 7189 CAD | 8647 NZD | 8507142 NGN | 6836 SGD | 3990 GBP | 5166 USD |
*The prices listed above are based on the cheapest package size and strength everyone.org has access to. Please make an enquiry for more specific pricing. The prices listed above are a guide only, we operate in Euros.
Fotivda (tivozanib) treatment costs
The cost for a monthly or yearly treatment of Fotivda (tivozanib) depends on your prescription requirements which includes the dosage in mg and medicine type (Capsules).
The price of the medicines you see on sale is the cost set by the manufacturer. In addition, shipping costs and a Named Patient support fee will apply.
Make an enquiry and we will help you calculate the total price to buy Fotivda (tivozanib) online and have it delivered where you live. From your side, we’ll simply need a prescription from your treating doctor. In some countries we might also need an import license. Our Patient Support team will guide you throughout the process.
Fotivda (tivozanib) price and additional costs
The price of Fotivda (tivozanib)
The base cost of each medicine is set by the manufacturer. Generally, our Named Patient support fee, shipping costs and any local tax (if applicable) are not included in the product price that is displayed on our website unless stated otherwise.
Our Named Patient support fee
everyone.org provides access to Fotivda (tivozanib) on the Named Patient import basis, which means that we work on behalf of the patient in cooperation with their treating doctor. Our Named Patient support fee covers sourcing, logistics and following up to make sure that the order is received safely and in perfect condition. The Named Patient support fee is tiered relative to the cost of the medicine.
Shipping costs
The shipping prices are dependent on the type of shipping necessary for the particular medicine (regular or cold chain) and upon the destination country. The shipping fees may include the shipping from our supplier to our partner pharmacy as well as the shipping costs to deliver the medicine to the patient’s country of residence. The shipping fee might also include the cost of special packaging, such as coolboxes, cool packs and data loggers, as well as transport insurance to guarantee that you receive your medicine in good order.
You can read a detailed overview of prices and costs here.
Payment methods when you buy Fotivda (tivozanib)
When you buy Fotivda (tivozanib), you can make the payment by bank transfer or by credit card. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
Fotivda (tivozanib) reimbursement
It might be possible for you to claim the cost of Fotivda (tivozanib) via your country's healthcare system. Some countries have a government fund providing financial assistance for citizens to access lifesaving medical treatment abroad. The best thing would be to check with your country's own health ministry. We also highly recommend checking out local patient blogs, communities and patient organisations to find out more about your options.
Medical insurance
Generally, we do not support medical insurance, but we do provide you with an invoice after you make the payment that you may send to your medical insurance company so they can reimburse you. In some limited circumstances, we do accept insurance. Contact us for more details. You can pay by bank transfer or credit card.
Crowdfunding
Crowdfunding might also be an option for you. It is a means of raising funds by using an online platform to group together many small donations from friends, family and others, in order to help you afford medical treatment. Here are some crowdfunding platforms where you can seek support: GoFundMe, GiveForward, FundRazr and Watsi.
Room temperature shipping
For this medication, standard shipping applies. This means that a consistent room temperature of 15 to 25°C is maintained during transit.
Your order will be shipped to you by our partner couriers, such as DHL, UPS and specialised cold chain couriers. If you would like your order to be shipped by a specific courier, please inform us when you place the order.
Our standard delivery time varies from 5 to 10 working days.
The shipping cost depends on the medicine and the destination country. After making an enquiry, you will receive a detailed quote that includes the shipping costs.
You can also pick up your medicine from our partner pharmacy in Amsterdam or our partner pharmacy in Luxembourg after the order has been paid for.
Four steps to access the medicines you need
How and where to access and buy Fotivda: You can access Fotivda from everyone.org if the drug has not been approved or is not available in your country.
-
Step 1
You send a request for your medicine online
Submit a request for a specific medicine, or a general request, and your Patient Support Manager will contact you within 24 hours. They will be there to support and guide you in anyway possible to help you get the medicine you need.
-
Step 2
We verify your prescription and medical details
Since we help patients access medicines not available in their home country, our first step is to check that the medicine you need is not currently available in your home country. Next we will also verify that you have a prescription from a doctor in your home country for the medicine you need.
-
Step 3
We source your medicine
Once we have verified your prescription and medical details, our expert sourcing team will work with our global network of suppliers to find you the best price. Once we have found you the lowest possible cost for your medicine, we will present you with a final offer for your approval.
-
Step 4
We deliver your medicine
After you have accepted our offer, our experienced logistics team will arrange all the shipping and transportation of your medicine. We will work hard to keep you informed at every step along the way and get your medicine to you quickly and safely. To date we have successfully delivered packages to over 75 countries around the world.
We are highly rated by our patients
Download your free guide on importing medicines into your country.
Provide your email below to receive a step-by-step guide to safely and legally importing medicines unavailable in your country.
Thank you!
You will receive an email with a download link to your guide (or a confirmation if you selected Other) at [email protected]. Please check your spam or junk folder.
Back to pageLet us help you
If you have any questions or need help, we're a phone call away. Our team is available from Monday to Friday between 9 a.m and 6 p.m CET
We usually respond to emails within 24 working hours
Call 
Email About us
We’re a dedicated team of medicine access experts, doctors and pharmacists. We come from all over the world. And we’ve lost family and friends who could not get the medicine they needed because they lived in the wrong country.
Our mission is to get everyone the right treatment at the right time. Wherever you live. Because you should not suffer or die if a treatment that could help you exists somewhere.
Learn moreAbout us
Learn how to access medicines
Learn moreFrequently Asked Questions
Read moreCompare medicines by disease
Disclaimer
We do our best to ensure the accuracy, currency, and completeness of the information provided here, but we can't guarantee it. Medicine information can change over time. The absence of a warning for a given medicine or combination of medicines should not be interpreted as confirmation that it’s safe, effective, or suitable for every patient. Always talk to your treating doctor before starting any treatment.
