Keytruda (pembrolizumab) vs Zynyz (retifanlimab-dlwr)
Keytruda (pembrolizumab) vs Zynyz (retifanlimab-dlwr)
Keytruda (pembrolizumab) and Zynlonta (loncastuximab tesirine-lpyl, not Zynyz) are both monoclonal antibodies used in cancer treatment, but they target different proteins and are used for different types of cancer. Keytruda targets the PD-1 receptor and is widely used for various cancers, including melanoma, lung cancer, and head and neck cancer, among others. Zynlonta, on the other hand, is an antibody-drug conjugate that targets CD19 and is used for the treatment of certain types of B-cell lymphomas. It is important for patients to consult with their healthcare provider to determine the most appropriate treatment based on their specific type and stage of cancer, as well as their overall health status.
Difference between Keytruda and Zynyz
Metric | Keytruda (pembrolizumab) | Zynyz (retifanlimab-dlwr) |
---|---|---|
Generic name | Pembrolizumab | Retifanlimab-dlwr |
Indications | Various types of cancers including melanoma, lung cancer, head and neck cancer, Hodgkin lymphoma, and others | Advanced or metastatic solid tumors with high microsatellite instability or mismatch repair deficiency |
Mechanism of action | Programmed death receptor-1 (PD-1) blocking antibody | Programmed death receptor-1 (PD-1) blocking antibody |
Brand names | Keytruda | Zynyz |
Administrative route | Intravenous infusion | Intravenous infusion |
Side effects | Fatigue, musculoskeletal pain, decreased appetite, pruritus, diarrhea, nausea, rash, fever, cough, dyspnea, constipation, pain in extremity, and headache | Similar to pembrolizumab, with potential for infusion-related reactions, fatigue, musculoskeletal pain, and others |
Contraindications | Severe hypersensitivity to pembrolizumab or any of its excipients | Severe hypersensitivity to retifanlimab or any of its excipients |
Drug class | Anti-PD-1 monoclonal antibody | Anti-PD-1 monoclonal antibody |
Manufacturer | Merck & Co. | Incysus Therapeutics, Inc. |
Efficacy
Efficacy of Keytruda (Pembrolizumab) in Treating Skin Cancer
Keytruda, also known by its generic name pembrolizumab, is a highly effective immunotherapy drug used in the treatment of various types of cancer, including skin cancer. It is particularly used for advanced stages of melanoma, a dangerous form of skin cancer. Pembrolizumab is a type of monoclonal antibody that works by blocking the PD-1 pathway, which cancer cells often exploit to hide from the immune system. By inhibiting this pathway, Keytruda enables the immune system to better recognize and destroy cancer cells.
Clinical trials have demonstrated that Keytruda significantly improves survival rates in patients with advanced melanoma. In some studies, pembrolizumab has shown a considerable increase in progression-free survival and overall survival compared to other treatments. Its efficacy has been observed both in patients who have not received prior treatment and in those who have progressed after other therapies. As a result, Keytruda has become a standard of care for advanced melanoma and has received approval from various regulatory agencies for this indication.
Efficacy of Zynyz (Retifanlimab-dlwr) in Treating Skin Cancer
Zynyz, with the generic name retifanlimab-dlwr, is a relatively new player in the field of immunotherapy for cancer treatment. As of the knowledge cutoff date in 2023, Zynyz is not specifically approved for the treatment of skin cancer. It is an anti-PD-1 therapy, similar to pembrolizumab, and is designed to help the immune system recognize and fight cancer cells. While it may hold potential for treating various types of cancer, including skin cancer, its efficacy in this particular area would be subject to the outcomes of clinical trials and research studies.
Since retifanlimab-dlwr is under investigation, any data on its efficacy for skin cancer would come from clinical trials that are either ongoing or completed. It is important for patients and healthcare providers to consult the latest research and clinical trial results to understand the potential benefits and risks of Zynyz in the context of skin cancer. As with any investigational drug, the efficacy and safety profile of retifanlimab-dlwr will be better understood once more data from these trials become available and regulatory authorities evaluate it for specific indications.
Regulatory Agency Approvals
Keytruda
Zynyz
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