Tibsovo (ivosidenib) vs Truseltiq (infigratinib)

Tibsovo (ivosidenib) is an oral medication specifically approved for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with a susceptible isocitrate dehydrogenase-1 (IDH1) mutation as detected by an FDA-approved test. Truseltiq (infigratinib) is also an oral medication, but it is indicated for the treatment of adults with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement as detected by an FDA-approved test. The choice between Tibsovo and Truseltiq would depend on the specific type of cancer a patient has and the presence of the respective genetic mutations; therefore, genetic testing and a discussion with a healthcare provider are essential to determine the appropriate treatment option.

Difference between Tibsovo and Truseltiq

Metric	Tibsovo (ivosidenib)	Truseltiq (infigratinib)
Generic name	Ivosidenib	Infigratinib
Indications	Acute myeloid leukemia (AML) with a specific genetic mutation (IDH1)	Previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with a specific genetic mutation (FGFR2)
Mechanism of action	Inhibits the mutant IDH1 enzyme, leading to a reduction in the oncometabolite 2-hydroxyglutarate (2-HG) levels	FGFR kinase inhibitor that blocks FGFR signaling and decreases cell proliferation
Brand names	Tibsovo	Truseltiq
Administrative route	Oral	Oral
Side effects	Fatigue, joint pain, diarrhea, dyspnea, edema, nausea, mucositis, QT interval prolongation, rash, fever, cough, constipation	Hyperphosphatemia, stomatitis, fatigue, alopecia, diarrhea, dry mouth, dysgeusia, nail toxicity, musculoskeletal pain, dry skin, decreased appetite, nausea, vomiting, constipation
Contraindications	Known hypersensitivity to ivosidenib or any of its excipients	Known hypersensitivity to infigratinib or any of its excipients
Drug class	Isocitrate dehydrogenase-1 (IDH1) inhibitor	Fibroblast growth factor receptor (FGFR) inhibitor
Manufacturer	Agios Pharmaceuticals, Inc.	QED Therapeutics, Inc.

Efficacy

Tibsovo (Ivosidenib) Efficacy in Bile Duct Cancer

Tibsovo, the brand name for ivosidenib, is a targeted therapy that has shown efficacy in the treatment of bile duct cancer, also known as cholangiocarcinoma, in patients with a specific genetic mutation. It is designed to inhibit the mutated form of the isocitrate dehydrogenase 1 (IDH1) enzyme, which is found in some patients with this type of cancer. The presence of the IDH1 mutation can be identified through molecular testing, and Tibsovo is intended for those who test positive for this mutation.

In clinical trials, Tibsovo demonstrated a significant impact on patients with IDH1-mutated cholangiocarcinoma. The response rate and duration of response were key measures of its efficacy. Patients treated with Tibsovo experienced a reduction in tumor size, with some achieving partial or complete responses. The median duration of response also suggested a potential for long-term benefit in a subset of patients.

Truseltiq (Infigratinib) Efficacy in Bile Duct Cancer

Truseltiq, known generically as infigratinib, is another targeted therapy that has been evaluated for its efficacy in treating bile duct cancer. Specifically, it targets abnormalities in the fibroblast growth factor receptor (FGFR) pathway, which can be altered in certain cancers, including cholangiocarcinoma. Truseltiq is used for patients who have a fusion or other rearrangement of FGFR2 (fibroblast growth factor receptor 2).

Clinical trials of Truseltiq have shown promising results for patients with FGFR2 fusion-positive cholangiocarcinoma. The drug has been associated with a meaningful response rate, indicating that a significant number of patients experienced tumor shrinkage. The duration of response and progression-free survival rates observed in the trials suggest that Truseltiq can provide a clinical benefit for patients with this specific genetic alteration in their bile duct cancer.

Regulatory Agency Approvals

Tibsovo

European Medical Agency (EMA), European Union
Food and Drug Administration (FDA), USA

Truseltiq

Food and Drug Administration (FDA), USA

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