Calquence (acalabrutinib) vs Velexbru (tirabrutinib hydrochloride)

Calquence (acalabrutinib) and Velexbru (tirabrutinib hydrochloride) are both Bruton's tyrosine kinase (BTK) inhibitors used in the treatment of certain blood cancers. Calquence is approved for the treatment of mantle cell lymphoma and chronic lymphocytic leukemia in some regions, offering a well-studied option with a known efficacy and side effect profile. Velexbru, while also a BTK inhibitor, may have different approvals and clinical uses depending on the region, and patients should consult with their healthcare provider to determine the most appropriate treatment based on their specific medical condition, the drug's approval status, and their individual health profile.

Difference between Calquence and Velexbru

Metric	Calquence (acalabrutinib)	Velexbru (tirabrutinib hydrochloride)
Generic name	Acalabrutinib	Tirabrutinib hydrochloride
Indications	Chronic lymphocytic leukemia (CLL), Small lymphocytic lymphoma (SLL), Mantle cell lymphoma (MCL)	Relapsed or refractory primary central nervous system lymphoma (PCNSL)
Mechanism of action	Bruton's tyrosine kinase (BTK) inhibitor	Bruton's tyrosine kinase (BTK) inhibitor
Brand names	Calquence	Velexbru
Administrative route	Oral	Oral
Side effects	Headache, diarrhea, muscle pain, neutropenia, anemia, thrombocytopenia, etc.	Fever, neutropenia, thrombocytopenia, rash, fatigue, etc.
Contraindications	Hypersensitivity to acalabrutinib or its excipients	Hypersensitivity to tirabrutinib or its excipients
Drug class	BTK inhibitor	BTK inhibitor
Manufacturer	AstraZeneca	Ono Pharmaceutical Co., Ltd.

Efficacy

Efficacy of Calquence (Acalabrutinib) in Treating Lymphoma

Calquence (acalabrutinib) is a Bruton tyrosine kinase (BTK) inhibitor that has shown efficacy in the treatment of certain types of lymphoma, particularly mantle cell lymphoma (MCL). In clinical trials, acalabrutinib has demonstrated a high overall response rate in patients with relapsed or refractory MCL. The drug works by inhibiting the BTK enzyme, which is essential for the growth and survival of malignant B cells. By targeting this pathway, acalabrutinib can reduce the proliferation of cancerous cells and induce apoptosis, leading to tumor shrinkage and clinical response in patients.

The efficacy of acalabrutinib in lymphoma was highlighted in a pivotal phase 2 clinical trial, where the majority of patients with relapsed or refractory MCL responded to the treatment, with a significant proportion achieving complete remission. The duration of response for these patients was also notable, with many experiencing prolonged periods of disease control. This has established acalabrutinib as an important treatment option for patients with this challenging form of lymphoma.

Efficacy of Velexbru (Tirabrutinib Hydrochloride) in Treating Lymphoma

Velexbru (tirabrutinib hydrochloride) is another BTK inhibitor that has been studied for its efficacy in treating lymphomas, particularly in patients with relapsed or refractory non-Hodgkin lymphoma (NHL). Similar to acalabrutinib, tirabrutinib targets the BTK enzyme, disrupting the signaling pathways necessary for the growth and survival of B-cell lymphomas. Clinical trials have demonstrated that tirabrutinib can induce responses in a significant number of patients with B-cell malignancies, including those who have failed previous therapies.

In a phase 2 clinical trial, tirabrutinib showed promising results in patients with Waldenström's macroglobulinemia, a rare type of non-Hodgkin lymphoma. The trial reported a high overall response rate, with many patients achieving partial or complete remission. These findings suggest that tirabrutinib could be a valuable therapeutic option for patients with B-cell lymphomas who have limited treatment choices due to disease progression or treatment resistance.

Regulatory Agency Approvals

Calquence

European Medical Agency (EMA), European Union
Food and Drug Administration (FDA), USA
Health Canada
Pharmaceuticals and Medical Devices Agency (PMDA), Japan
Therapeutic Goods Administration (TGA), Australia

Velexbru

Pharmaceuticals and Medical Devices Agency (PMDA), Japan

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